Project Title: Clinical Trial to Evaluate the Safety and Immunogenicity in Age De-Escalation of Direct Venous Inoculation of a Plasmodium falciparum Sporozoite Vaccine in Tanzanian Adults, Children, and Infants

Project Description: A single center, double blind, randomized, normal saline placebo-controlled trial of PfSPZ vaccine OR PfSPZ challenge, administered by Direct Venous Inoculation (DVI). The trial is aimed at evaluating safety, tolerability and vaccine-induced humoral and cellular immune responses of PfSPZ Vaccine in healthy male and female Tanzanian adults, adolescents, children, and infants (from 6 months old) who receive doses of 1.8×10⁶, 9.0×10⁵, 4.5×10⁵ or 2.7×10⁵ PfSPZ of PfSPZ and to assess efficacy in adults three weeks... A single center, double blind, randomized, normal saline placebo-controlled trial of PfSPZ vaccine OR PfSPZ challenge, administered by Direct Venous Inoculation (DVI). The trial is aimed at evaluating safety, tolerability and vaccine-induced humoral and cellular immune responses of PfSPZ Vaccine in healthy male and female Tanzanian adults, adolescents, children, and infants (from 6 months old) who receive doses of 1.8×10⁶, 9.0×10⁵, 4.5×10⁵ or 2.7×10⁵ PfSPZ of PfSPZ and to assess efficacy in adults three weeks and twenty four weeks following immunization using Controlled Human Malaria Infection (CHMI). A total of 105 subjects will be enrolled at the trial completion Read more

Principal Investigator : Said Jongo

Department Name : BRCT

Time frame: (2015-08-01) - (2018-12-31)

Funding Partners
Medical Care Development International (MCDI) (Normal)
External Collaborating Partners
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